Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective
Allopregnanolone is synthesized in the central Aids To Daily Living nervous system either de novo from cholesterol or from steroid hormone precursors like progesterone and pregnenolone.Over the past 30 years, direct and rapid, non-genomic actions of allopregnanolone and its derivatives via GABAA receptors have been demonstrated.Changes in brain lev